PART IV Drugs used in disorders of coagulation
01. All of the following physiologic reactions are involved in the control of bleeding EXCEPT:
a) Platelet adhesion reaction
b) Platelet release reaction
c) Activation of the antifibrinolytic system
d) Triggering of the coagulation process
02. Which of the following substances is synthesized within vessel walls and inhibits thrombogenesis?
a) Thromboxane A2 (TXA2)
b) Prostacyclin (PGI2)
c) Prostaglandin ((PGE)
d) None of the above
03. All of the following groups of drugs are for thrombosis treatment EXCEPT:
a) Anticoagulant drugs
b) Antifibrinolitic drugs
c) Fibrinolitic drugs
d) Antiplatelet drugs
04. Pick out the drug belonging to anticoagulants of direct action:
a) Aspirin
b) Heparin
c) Dicumarol
d) Phenprocoumon
05. Which of the following drugs has low-molecular weight?
a) Dicumarol
b) Enoxaparin
c) Phenprocoumon
d) Heparin
06. Indicate the drug belonging to antagonists of heparin:
a) Aspirin
b) Dicumarol
c) Dalteparin
d) Protamine sulfate
07. Tick the drug used as an oral anticoagulant:
a) Heparin
b) Daltreparin
c) Dicumarol
d) Enoxaparin
08. All of the following drugs are indirect acting anticoagulants EXCEPT:
a) Dicumarol
b) Warfarin
c) Dalteparin
d) Phenindione
09. Which of the following drugs belongs to coumarin derivatives?
a) Heparin
b) Enoxaparin
c) Dalteparin
d) Warfarin
10. Heparin is effective when administred orally. This consideration is:
a) True
b) False
11. All of these drugs are antiplatelet agents EXCEPT:
a) Aspirin
b) Urokinase
c) Ticlopidine
d) Clopidogrel
12. The use of heparin is recommended for treatment of deep venous thrombosis. This statement is:
a) True
b) False
13. Mechanism of aspirin action is:
a) Converts inactive plasminogen into active plasmin
b) Inhibits COX and thus thromboxane synthesis
c) Enhances the interaction between antitrombin III and both thrombin and the factors involved in the intrinsic clotting cascade
d) Inhibits the glycoprotein IIb/IIIa complex
14. Which doses of Aspirin may be more effective in inhibiting Tromboxane A2?
a) Low
b) High
15. Which of the following drugs is an inhibitor of platelet glycoprotein IIb/IIIa receptors?
a) Aspirin
b) Clopidogrel
c) Ticlopidine
d) Abciximab
16. Ticlopidine is an inhibitor of ADP-induced platelet aggregation. It’s:
a) True
b) False
17. Which of the following drugs is fiibrinolytic?
a) Ticlopidine
b) Streptokinase
c) Aspirin
d) Warfarin
18. Mechanism of urokinase action is an inhibition of Thromboxane A2. This statement is:
a) True
b) False
19. Fibrinolytic drugs are used for following EXCEPT:
a) Central deep venous thrombosis
b) Multiple pulmonary emboli
c) Heart failure
d) Acute myocardial infarction
20. Indicate the drug belonging to fibrinoliytic inhibitors:
a) Aminocapronic acid
b) Ticlopidine
c) Streptokinase
d) Vitamin K
21. Aminocapronic acid is a drug of choice for treatment of:
a) Acute myocardial infarction
b) Bleeding from fibrinolytic therapy
c) Heart failure
d) Multiple pulmonary emboli
22. Tranexamic acid is an analog of aminocapronic acid. It’s:
a) True
b) False
