PART VIII Antihypertensive drugs
01. This drug reduces blood pressure by acting on vasomotor centers in the CNS:
a) Labetalol
b) Clonidine
c) Enalapril
d) Nifedipine
02. All of the following are central acting antihypertensive drugs EXCEPT:
a) Methyldopa
b) Clonidine
c) Moxonidine
d) Minoxidil
03. A ganglioblocking drug for hypertension treatment is:
a) Hydralazine
b) Tubocurarine
c) Trimethaphan
d) Metoprolol
04. Pick out the sympatholythic drug:
a) Labetalol
b) Prazosin
c) Guanethidine
d) Clonidine
05. Tick the drug with nonselective beta-adrenoblocking activity:
a) Atenolol
b) Propranolol
c) Metoprolol
d) Nebivolol
06. Choose the selective blocker of beta-1 adrenoreceptors:
a) Labetalol
b) Prazosin
c) Atenolol
d) Propranolol
07. Pick out the drug – an alpha and beta adrenoreceptors blocker:
a) Labetalol
b) Verapamil
c) Nifedipine
d) Metoprolol
08. This drug inhibits the angiotensin-converting enzyme:
a) Captopril
b) Enalapril
c) Ramipril
d) All of the above
09. This drug is a directly acting vasodilator:
a) Labetalol
b) Clonidine
c) Enalapril
d) Nifedipine
10. Pick out the diuretic agent for hypertension treatment:
a) Losartan
b) Dichlothiazide
c) Captopril
d) Prazosin
11. This drug blocks alpha-1 adrenergic receptors:
a) Prazosin
b) Clonidine
c) Enalapril
d) Nifedipine
12. This drug activates alpha-2 adrenergic receptors:
a) Labetalol
b) Phentolamine
c) Clonidine
d) Enalapril
13. This drug is an inhibitor of renin synthesis:
a) Propranolol
b) Enalapril
c) Diazoxide
d) Losartan
14. This drug is a non-peptide angiotensin II receptor antagonist:
a) Clonidine
b) Captopril
c) Losartan
d) Diazoxide
15. This drug is a potassium channel activator:
a) Nifedipine
b) Saralasin
c) Diazoxide
d) Losartan
16. All of the following statements regarding angiotensin II are true EXCEPT:
a) It is a peptide hormone
b) It stimulates the secretion of aldosterone
c) Angiotensin I is almost as potent as angiotensin II
d) It is a potent vasoconstrictor
17. This drug is contraindicated in patients with bronchial asthma:
a) Propranolol
b) Clonidine
c) Enalapril
d) Nifedipine
18. This drug is converted to an active metabolite after absorption:
a) Labetalol
b) Clonidine
c) Enalapril
d) Nifedipine
19. This drug routinely produces some tachycardia:
a) Propranolol
b) Clonidine
c) Enalapril
d) Nifedipine
20. All of the following statements regarding vasodilators are true EXCEPT:
a) Hydralazine causes tachycardia
b) Nifedipine is a dopamine receptor antagonist
c) Nitroprusside dilates both arterioles and veins
d) Minoxidil can cause hypertrichosis
21. All of the following statements regarding verapamil are true EXCEPT:
a) It blocks L-type calcium channels
b) It increases heart rate
c) It relaxes coronary artery smooth muscle
d) It depresses cardiac contractility
22. Choose the unwanted effects of clonidine:
a) Parkinson’s syndrome
b) Sedative and hypnotic effects
c) Agranulocytosis and aplastic anemia
d) Dry cough and respiratory depression
23. The reason of beta-blockers administration for hypertension treatment is:
a) Peripheral vasodilatation
b) Diminishing of blood volume
c) Decreasing of heart work
d) Depression of vasomotor center
24. An endogenous vasoconstrictor that can stimulate aldosterone release from suprarenal glands:
a) Angiotensinogen
b) Angiotensin I
c) Angiotensin II
d) Angiotensin-converting enzyme
25. Choose the group of antihypertensive drugs which diminishes the metabolism of bradykinin:
a) Ganglioblockers
b) Alfa-adrenoblockers
c) Angiotensin-converting enzyme inhibitors
d) Diuretics
26. Hydralazine (a vasodilator) can produce:
a) Seizures, extrapyramidal disturbances
b) Tachycardia, lupus erhythromatosis
c) Acute hepatitis
d) Aplastic anemia
27. Choose the vasodilator which releases NO:
a) Nifedipine
b) Hydralazine
c) Minoxidil
d) Sodium nitroprusside
28. The reason of diuretics administration for hypertension treatment is:
a) Block the adrenergic transmission
b) Diminishing of blood volume and amount of Na+ ions in the vessels endothelium
c) Depression of rennin-angiotensin-aldosterone system
d) Depression of the vasomotor center
29. Tick the diuretic agent – aldosterone antagonist:
a) Furosemide
b) Spironolactone
c) Dichlothiazide
d) Captopril
30. Tick the diuretic agent having a potent and rapid effect:
a) Furosemide
b) Spironolactone
c) Dichlothiazide
d) Indapamide
