Skin pathology mcqs

  1. Which ONE of the following is not a virus infection of the skin?
    A. Condyloma acuminatum.
    B. Molluscum contagiosum.
    C. Pemphigus vulgaris.
    D. Verruca vulgaris.
    E. Zoster.
    The answer is C. Pemphigus vulgaris is an inflammatory condition characterized by
    the presence of intraepidermal bullous formation; there is circulating IgG class antibody to
    intercellular substance of squamous epithelium.
  2. Dermatitis herpetiformis is associated with which ONE of the following
    A. Ankylosing spondylitis.
    B. Coeliac disease.
    C. Diverticulitis.
    D. Emphysema.
    E. Whipple’s disease.
    The answer is B. The majority of patients with dermatitis herpetiformis have small
    intestinal villous abnormalities, and the intestinal lesions will repond to gluten withdrawal.
  3. For each of the types of skin lesion listed on the left select the most appropriate
    association from those on the right.
    a. Basal cell carcinoma.
    b. Bowen’s disease.
    c. Moluscum sebaceum.
    A. Squamous carcinoma-in-situ on the legs.
    B. Squamous carcinoma-in-situ on sun-exposed skin.
    C. Tumour of sweat gland.
    D. Tumour-like self-healing lesion.
    E. Very rarely metastasizes.
    The answer is E, A, D. Basal cell carcinomas (rodent ulcers) are locally agressive and
    destructive tumours which very rarely metastasize.
    Carcinoma-in-situ of the skin may develop in areas not exposed to sunlight.
    The importance of molluscum sebaceum is that it resembles squamous carcinoma
    histologically, but is entirely benign.
  4. For each of the types of pigmented skin lesions listed on the left select the most
    appropriate association from the list on the right.
    a. Compound pigmental naevus.
    b. Lentigo maligna.
    c. Nodular melanoma.
    A. Growth phase vertical only.
    B. Increase in basal layer melanocytes.
    C. Melanocytes in dermis and epidermis.
    D. Presents on soles of feet.
    E. Slow-growing flat pigmented lesion.
    The answer is C, A, E. Pigmented naevi are benign conditions in which there are
    increased numbers of melanocytes; the compound naevus is the commonest type in childhood.
    Melanocytes are in dermis and epidermis.
    The lentigo maligna (Hutchinson’s melanotic freckle) is essentially a malignant
    melanoma-in-situ. It is a slow-growing flat pigmented lesion.
    Malignant melanomas have a horizontal and vertical growth phase; nodular melanoma
    appears to have a vertical phase with no preceding horizontal phase. Increased basal layer
    melanocytes are seen in a lentigo (B). A malignant melanoma which presents on the soles or
    palms is known as an acral lentiginous melanoma (D).

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